Milestones

Successful milestones

  • De- and recellularization of a blood vessel (a vein without valves) using bone-marrow stem cells

 

  • Developing solutions and media needed to facilitate the de- and recellularization process

 

  • Adaptation of the de-/recellularization technique to veins with valves

 

  • Development of a refined procedure for recellularizing blood vessels, which is now ready for scale up in a regulatory correct environment (GMP)

 

  • Development of a technique for isolation of stem cells from peripheral whole blood

 

  • Successful transplantation of tissue engineered blood vessels to 3 pedriatric patients

 

Future milestones

  • Further development of the technique of using peripheral blood stem cells

 

  • Applying the technology to develop also tissue-engineered arteries

 

  • GMP accreditation of the production of media and solutions for the de- and recellularization of blood vessels

 

  • GMP accreditation of the process for developing recellularized blood vessels

 

  • Performing a clinical study with Personalized Tissue Engineered Veins (P-TEV)

 

  • Establishing a regulatory roadmap

 

  • Scaling production of tissue-engineered veins and arteries
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